Non-expert summaryThe displacement of one liquid by another in a channel of constant height occurs in flushing and cleaning operations. The authors study the effect of buoyancy (arising from different fluid densities) on a pressure-driven flow of two miscible fluids in inclined channels using direct numerical simulations DNS). The flow dynamics are governed by the continuity and Navier–Stokes equations, without the Boussinesq approximation for buoyancy, coupled to a convective-diffusion equation for mass transfer between the two liquids. The effect of concentration on viscosity and density is modelled. The effect of varying the density ratio, Froude number, and channel inclination on the flow dynamics is examined, for moderate Reynolds numbers. These detailed simulations give insights into mixing and cleaning behaviour.